Foundational technology to make cancer cells revert to normal cells?

[Richard D]

This seems like it could be quite significant.

Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to eliminate cancer cells. This approach, however, faces fundamental limitations, including cancer cells developing resistance and returning, as well as severe side effects from the destruction of healthy cells.

KAIST (represented by President Kwang Hyung Lee) announced on the 20th of December that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering has developed a groundbreaking technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.

The research team focused on the observation that during the oncogenesis process, normal cells regress along their differentiation trajectory. Building on this insight, they developed a technology to create a digital twin of the gene network associated with the differentiation trajectory of normal cells.

Through simulation analysis, the team systematically identified master molecular switches that induce normal cell differentiation. When these switches were applied to colon cancer cells, the cancer cells reverted to a normal-like state, a result confirmed through molecular and cellular experiments as well as animal studies.

https://www.sciencedaily.com/releases/2024/12/241223135214.htm

Original journal publication: https://onlinelibrary.wiley.com/doi/10.1002/advs.202402132

[global1]

1. I Sure Hope This Is Developed, Approved And It Works......

My Dad died of colon cancer at the age of 39. I was 12 at the time. I'm 76y/o now. I miss my Dad. It would sure be great if they can cure colon cancer!!!

[rampartd]

2. billionaires die of cancer like everyon else

this research will continue, and we will pay for it, but most will not afford the treatment.

my arguement for universal health care involves the results of taxpayer funded research not being available the taxpayers.

[Native]

3. this is amazing