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Treating Diabetes Without Drugs? Novel Non-pharmacologic Treatments on the Horizon [View all]
https://medicine.yale.edu/news-article/treating-diabetes-without-drugs-novel-non-pharmacologic-treatments-on-the-horizon/
Treating Diabetes Without Drugs? Novel Non-pharmacologic Treatments on the Horizon
March 31, 2022
by Jane E. Dee
Amulti-institutional team including Yale School of Medicine (YSM) has demonstrated the ability to use ultrasound to stimulate specific neurometabolic pathways in the body to prevent or reverse the onset of type 2 diabetes in three different preclinical models. The team, which includes the lab of Raimund Herzog, MD, MHS, at YSM, reported its findings in Nature Biomedical Engineering.
The team of investigators is now conducting human feasibility trials with type 2 diabetic subjects, moving medicine closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections, and drug treatments. The goal of the studies is to provide a long-lasting treatment for people with type 2 diabetes to alleviate and potentially reverse the disease.
Type 2 diabetes affects millions of people worldwide. The long-term condition results in too much sugar circulating in the bloodstream. Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation.
Herzog, associate professor (endocrinology) in the Department of Internal Medicine at YSM and a member of the NIH-funded Yale Diabetes Research Center, and his lab tested the magnitude of the effect of ultrasound treatment on blood glucose. "Even though we already have a large variety of anti-diabetic medications available to us to treat high glucose levels, we are always looking for new ways to improve insulin sensitivity in diabetes,” Herzog said.
[...]
March 31, 2022
by Jane E. Dee
Amulti-institutional team including Yale School of Medicine (YSM) has demonstrated the ability to use ultrasound to stimulate specific neurometabolic pathways in the body to prevent or reverse the onset of type 2 diabetes in three different preclinical models. The team, which includes the lab of Raimund Herzog, MD, MHS, at YSM, reported its findings in Nature Biomedical Engineering.
The team of investigators is now conducting human feasibility trials with type 2 diabetic subjects, moving medicine closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections, and drug treatments. The goal of the studies is to provide a long-lasting treatment for people with type 2 diabetes to alleviate and potentially reverse the disease.
Type 2 diabetes affects millions of people worldwide. The long-term condition results in too much sugar circulating in the bloodstream. Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation.
Herzog, associate professor (endocrinology) in the Department of Internal Medicine at YSM and a member of the NIH-funded Yale Diabetes Research Center, and his lab tested the magnitude of the effect of ultrasound treatment on blood glucose. "Even though we already have a large variety of anti-diabetic medications available to us to treat high glucose levels, we are always looking for new ways to improve insulin sensitivity in diabetes,” Herzog said.
[...]
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