A large-scale genome-wide association study meta-analysis of cannabis use disorder.

[NNadir]

2. I don't buy this putative "difference" at all.

There is can't stop, as in very, very, very difficult to stop. I do hope my nephew will find that path to stop, but I think as a family we're very clear that it isn't just a matter of will.

This is hardly the only article on the subject in the scientific literature, as opposed to "I see it all the time."

It's not like I haven't had half a century of exposure to this issue myself, but I am not relying on anecdote and nonsystematic opinion.

Most addicts to any substance will claim that they can stop using an addictive substance that has become an abuse issue, but when tested on the topic, they fall short of their self described ability to manage use. Reason they can't stop isn't because they are weak willed; they can't stop for reasons that are clearly involve molecular biology.