A large-scale genome-wide association study meta-analysis of cannabis use disorder.

[Warpy]

12. My problem with that study is the consistent cart-horse mismatch

one finds so often in these studies, the conclusion that cannabis caused a problem when its use was actually an attempt to treat a serious underlying problem. It's bad science and smells very strongly of confirmation bias.

Case in point: my own family runs to bipolar disease, and the first thing the people who have it tend to do is start using alcohol. Drinking works to numb the depression and blunt the mania, and they might even get a few years of decent treatment that way, but alcohol also produces tolerance, meaning they need to drink more to get the same effect, and a withdrawal process that's 50% fatal if done suddenly and with no medical supervision. Mostly, they hit the 5 or so year mark as bipolar alcoholics. If they detox, does that mean detoxing from alcohol made them bipolar? No, it means they were undiagnosed and medicating with a substance that only worked short term while producing physical dependency..

Try asking your nephew if he can remember what he felt like before he started using cannabis. You might find the answer very enlightening.