Scientists Reverse Alzheimer's Memory Loss by Repairing Damaged Synapses

[JudyM]

9. Part of the study involved mice, and part involved humans.

The strong correlation they found between level of cognitive decline in human subjects and deficiency of KIBRA found in their brains is, itself, a promising discovery.

Increasing the KIBRA level to see what would happen was done with mice.

Developing a treatment and getting it successfully through Phase 3 clinical studies still needs to happen. But the concept that there is an end-run mechanism around tau buildup broke new ground that researchers can explore.

As I’m reading about this, I’m seeing that recognition of an association between KIBRA and memory has been around for at least 15-20 years (I didn’t look for the first instance, but studies started popping up around then; there was even a study suggesting that chess and science ability might be connected to a particular KIBRA allele!) without much followup progress into how it worked. Looking around online it appears there may even be dietary interventions we can explore, ourselves, for boosting KIBRA though I’ve only just started looking at this…