Rochester NY for almost 30 years. Mom is still in the Hospitality/Tourism industry there so kind of grew up with the history of the region. Also familiar with your road route. 
You are going to come across 90 right?
You have to pass Rochester to get out to Seneca Falls - and it's not even an hour away.
Stop here first: http://susanbanthonyhouse.org/index.php. I think they are open on Saturday.
Then head to Seneca. Never been as a "destination" per se - but I have most definitely been there!
Another interesting woman that is of interest in Central NY - http://harriethouse.org/
Psst - Buff to Roch is Western NY. Syracuse are is Central NY. Don't tell the folks in NYC but they don't like the "upstate" thing. . Live in NJ now but . . . I still say "we are different out west". 
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